What is Peritoneal Mesothelioma?

It is a cancer located in the stomach lining. It can be defined more precisely as cancer of the cells that comprise the lining around the lungs, pleura, peritoneum, or other areas of the body. It is also sometimes referred to as Abdominal Mesothelioma.

What are the causes of Peritoneal Mesothelioma?

Although there's no definitive explanation about its cause, it is widely believed that asbestos causes Peritoneal Mesothelioma in one of two ways.

First, asbestos fibers may be ingested, and when in the intestinal tract, the fibers may work themselves into the peritoneal cavity and peritoneum.

Second, they may be inhaled and transported through the lymph node system to the peritoneal cavity.

What are the Symptoms of Peritoneal Mesothelioma?

There are a number of symptoms for this disease. However, there is a very long latency period, and symptoms may not become evident for decades after exposure because of which it is often already too late to offer any real constructive treatment. A further delay can be caused due to the fact that the symptoms are generally non-specific and can therefore be attributed to a number of more common ailments.

The symptoms of Peritoneal Mesothelioma include: abdominal pains and weakness; weight loss; nausea; loss off appetite; abdominal swelling; bowel obstruction. Depending on the location of the tumour, additional problems can be experienced such as breathing problems and severe pains.

What is the cure for Peritoneal Mesothelioma?

There are various methods for treating Peritoneal Mesothelioma :

1. Surgery

Surgery involves removing part of the lining or the tissue from the abdomen in order to remove the tumor. Size of the tissue removed depends upon the doctor and the intensity of the cancer. Sometimes, a lung or some other organ may be removed to carry out successful removal of cancer.

2. Radiation therapy

In radiation therapy, high energy X-rays are used to shrink the tumors and kill cancerous cells in the affected parts of the body. Radiation therapy may be administered by external means in which radiation is passed on to the body. Sources of radiation can also be placed inside the affected areas with the help of plastic tubes.

3. Chemotherapy

In this form of treatment, a combination of drugs is administered to the patients to kill the cancerous cells. Drugs can be either taken orally or intravenously. The drug travels in the body and works on the affected cells killing cancerous ones.

4. Medicine • Arthritis Drugs have shown promising effects for Mesothelioma patients • FDA has approved a combination of Alimta-Cisplatin for treatment of asbestos-related cancer.

What are the precautions that are to be taken to be more aware of the risks of Peritoneal Mesothelioma?

Although a rare form of cancer, it is caused due to exposure to asbestos and people working in an industry where asbestos is handled should be very careful about their health. They should make annual visits to their doctor so any hint of the disease can be dealt with in early stages.

Monday, June 4, 2007

Asbestos-induced peritoneal mesothelioma in a construction worker - Grand Rounds

Environmental Health Perspectives, April, 2004 by Rodolfo Fonte, Salvatore Gambettino, Mario Melazzini, Mario Scelsi, Claudio Zanon, Stefano M. Candura

Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent ascites after having been exposed to asbestos in the building industry for > 40 years. Liver function and histology were normal. Abdominal computed tomography initially excluded the presence of expansive processes, and no abnormal cells were found in the ascitic fluid. Laparoscopy showed diffuse neoplastic infiltration of the peritoneum. Histopathology of bioptic samples revealed epithelioid neoplastic proliferation with a tubulopapillary pattern, falsely suggesting metastatic adenocarcinomatosis. In consideration of the occupational history, and after further diagnostic procedures had failed to identify the hypothetical primitive tumor, immunostaining of the neoplastic tissue was performed. Results were negative for carcinoembrionary antigen and the epithelial glycoprotein Ber-EP4, whereas results were positive for the mesothelial markers cytokeratins, calretinin, epithelial membrane antigen, and HBME-1, thus leading to the correct diagnosis of peritoneal epithelial mesothelioma. The Italian Workers' Compensation Authority recognized the occupational origin of the disease. Cytoreductive surgery associated with continuous hyperthermic peritoneal perfusion (cisplatin at 42[degrees]C, for 1 hr) was performed. The disease relapsed after 4 months and was later complicated by a bowel obstruction requiring palliative ileostomy. The patient died 23 months after diagnosis. This case illustrates the insidious diagnostic problems posed by peritoneal mesothelioma, a tumor which often simulates other malignancies (e.g., metastatic carcinomas) at routine histopathological examination. Occupational history and immunohistochemistry are helpful for the correct diagnosis, which, in turn, is important in relation to prognosis and treatment (adoption of new integrated procedures that seem to promise prolonged survival and increased quality of life), and in relation to medicolegal issues and occupation-related compensation claims following asbestos exposure. Key words: calretinin, cisplatin, HBME-1, intraperitoneal chemotherapy, occupational cancer, peritonectomy.

Case Presentation

In June 2000 a 65-year-old man was hospitalized for recently developed ascites, indefinite abdominal pain, dyspepsia, and mild hepatomegaly (echographic finding). He reported occasional abuse of alcoholic beverages and lifelong heavy smoking (40 cigarettes/day). The patient had worked in the building industry from 14 to 55 years of age (1949-1990), when he retired. His duties (installation of industrial roofing, pipes, flues, and tanks) required cutting and shaping asbestos-cement panels with an electric saw and a rotating abrasive disk, exposing him to the inhalation of asbestos fibers. Routine blood and urine analyses (including indicators of liver function) were normal. Viral hepatitis (B and C) markers were negative. Chest radiography and lung function tests revealed chronic obstructive pulmonary disease (COPD). Esophagogastroduodenoscopy disclosed mild gastroduodenitis. Abdominal computed tomography (CT) excluded the presence of expansive processes. Evacuative paracentesis was performed: the ascitic fluid was clear, and cytologic analysis did not detect abnormal cells.

In the following months, ascites reformed quickly after repeated paracentesis. Percutaneous liver biopsy (December 2000) showed normal hepatic histology. Laparoscopy (April 2001) revealed diffuse neoplastic infiltration of the peritoneum and greater omentum, with a carcinomatous aspect. Several bioptic samples were collected; standard histopathologic examination demonstrated epithelioid neoplastic proliferation with a tubulopapillary pattern (Figure 1), suggesting metastatic peritoneal adenocarcinomatosis. Further diagnostic procedures (colorectal radiology and endoscopy, magnetic resonance imaging of the abdomen, chest CT, and pelvic, transrectal, and testicular ultrasonography) failed to identify the hypothetical primitive tumor. The occupational history of long-term asbestos exposure prompted us to conduct immunohistochemical tests on the neoplastic tissue samples. Staining for the carcinoembrionary antigen (CEA) and the epithelial glycoprotein Ber-EP4 was negative, whereas results for the mesothelial markers cytokeratins, calretinin (Figure 2), epithelial membrane antigen (EMA), and HBME-1 (Figure 3) were positive, leading to the diagnosis of peritoneal epithelial mesothelioma.


In May 2001 the patient underwent bilateral subphrenic peritonectomy, partial pancreasectomy, splenectomy, appendicectomy, and cytoreductive debulking of neoplastic nodules larger than 3 mm. This was followed by peritoneal perfusion with cisplatin heated at 42[degrees]C for 1 hr. After overcoming severe postoperative complications (delayed adynamic ileus, Candida tropicalis septicemia, and Clostridium difficile bowel infection), the patient was discharged in fairly good conditions (July 2001). He remained apparently free of disease for 4 months, after which ascites reformed. Abdominal ultrasonography indicated disease relapse.

No comments: